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On theoretical grounds, excretion in human milk should be low since these molecules are uncharged and highly protein bound in plasma, their molecular weight is fairly low however 400 Da (12, 5355) ( Supplement 3 )

While still prescribed, clinical guidelines increasingly favor semaglutide or tirzepatide for patients who are candidates for GLP-1 therapy

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The Standards of Medical Care in Diabetes, updated annually, includes dedicated sections on incretin-based therapies relevant for understanding tirzepatide pharmacology and clinical application

Glycine is an amino acid stabilizer that helps maintain the tirzepatide peptide structure and pH during storage