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The formation of the inflammasome leads to the activation of caspase-1, which has been confirmed to initiate sustained inflammation by maturating and releasing interleukin-1 (IL-1) and IL-18 [6]

Furthermore, in streptozocin (STZ i.c.v) -induced AD rats (77) and APP/PS1 mice (78), DPP-4 inhibitors sitagliptin and saxagliptin were observed to have the ability to eliminate A accumulation, clear abnormal phosphorylation of tau, and improve brain mitochondrial dysfunction probably through activation of AMPK in neuronal cells (66)

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PCOS is a hormonal problem that impacts women who can get pregnant

Keep a list of current meds to check for interactions