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With this background, GLP-1RAs might provide an opportunity to break the remarkable inflammation process, exerting broad anti-inflammatory actions and reducing biomarkers of systemic inflammation in particular in human subjects with type 2 diabetes and people with obesity ( Despite a large body of scientific research, GLP-1RA demonstrated a positive effect with a 14% reduction in major cardiovascular events (MACE) [HR=0.86, 95%CI(0.79-0.94), p =0.006] and no significant heterogeneity was observed between subgroups of individuals with or without cardiovascular disease ( p =0.127)

Dietary restraint scores improved, indicating enhanced ability to consciously limit food intake without excessive psychological burden

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