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It also modulates matrix metalloproteinases, promoting remodeling rather than simple synthesis

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Dose adjustment is not recommended in patients with mild-severe renal impairment (eGFR = 15-89 mL/min/1.73 m 2 ), but use is not recommended for patients with end-stage renal disease (127)

The core populations to prioritize are: Adults with overweight or obesity plus at least one additional risk factor including