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For example, one study showed that although people treated for 68 weeks with semaglutide (2.4 mg/week) lost an average of 18% of their initial body weight, the majority of this weight was regained within a year following discontinuation of treatment (Figure 7)

This has resulted in several investigators concluding that its effects are irreversible, since in tissue environments its effects can last many days to weeks (German et al 2015)

This slow phase is indicative of equilibrium overshoot, where electrons initially flow into the enzyme and then fractionally return to NADPH at equilibrium

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