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Natl Vital Stat Rep 58:1132 Charache S, Barton FB, Moore RD, Terrin ML, Steinberg MH, Dover GJ, Ballas SK, McMahon RP, Castro O, Orringer EP (1996) Hydroxyurea and sickle cell anemia

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Similar to CM, the MAPK cascade is hyperactivated by altered genes in MM including NRAS , BRAF , NF1 , and SPRED1 , thereby making inhibition of MAPK signal transduction a promising treatment strategy for MM patients