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Despite advances in phenotypic and mechanistic characterization of three distinct permeability pathways, development of experimental agents that specifically target these pathways, and remarkable efficacy in preclinical models, pathway-targeted therapies have not been tested in human subjects

The FDA does not have to follow PCAC recommendations, but it almost always does and when it doesnt, the divergence becomes its own news

These effects may include improved cell survival, support for follicular signaling, and increased elongation of isolated hair follicles

However, factors such as formulation effectiveness and route of administration-related adverse effects, may influence patient experience and clinical utility

Patient factors still matter too, especially kidney, heart, or liver disease, medication use, allergies, and G6PD status