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Studies have demonstrated that this transporter is one of the ABC pumps with the highest-level of expression in organs important for endo- and xenobiotic metabolism, such as the liver, kidneys, and intestine [81]

This CRISPRa system that has been described has recently been applied in several animal models of NDDs

Ascioti AJ, Hofstetter WL, Miller MJ, Rice DC, Swisher SG , Vaporciyan AA, Roth JA, Putnam JB, Smythe WR, Walsh GL

2018;46:W486W494