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Approvals for the immunotherapies Keytruda (-PD-1 mAb) and Kymriah (CD19 CAR-T) were turning points in the fight against cancerthese successes paved the way for dozens of other biotechs and large pharma to develop their own PD-1- or CD19-targeting agents

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Secondary resistance in patients who showed an initial response has actually been thought to be due to de novo mutations located on regions in smoothened to which hedgehog pathway inhibitors bind or selective clonal expansion of minority clones in the pre-treated tumor