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It has also shown a likely practical, cytoprotective significant effect, in duodenal ulcer and disease, applicable as a further wound healing therapy in fistulas along with the beneficial effect on other fistula healing (10-12) that should be more than experimentally relevant providing its initial use in the ulcerative colitis trials and its very safe profile (4-9, 29)
This process, along with GCL inhibition and the formation of mixed disulfides between GSH and protein sulfhydryl, concurred to a steady-state decrement of free GSH concentration and, consequently, to an intracellular redox state shift toward more oxidizing conditions, which could be required for avoiding fast reduction of oxidized cysteines allowing the upstream ROS-induced autophagic stimulus to be propagated
Conclusions: We do not report altered GSH concentrations in the ACC or DLPFC in PTSD, however, systemic MMPs and MPO might be implicated in central processes and progression of PTSD