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Rapid activation of a bypassing loop[21-25] occurs in rats with an infrarenal ligation of the inferior vena cava, relieving a Virchow's triad situation[21], much like in rats with ischemic/reperfusion colitis[22], duodenal venous congestion lesions[23], perforated cecum[24], bile duct ligation induced liver cirrhosis and portal hypertension[25]
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The failure to directly detect GSS by us and others 31,32 is in line with their stability toward other molecules (including spin traps) on the one hand and their rapid disappearance (through self-recombination) on the other
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