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JAMA Otolaryngol Head Neck Surg 151(2):113-120, 2025

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Non-surgical: Compression garments, skin-tightening treatments, exercise 2

The SURMOUNT-4 trial assessed the weight maintenance with tirzepatide and had also two periods: a 36-week open-label lead-in period during which all participants took tirzepatide, followed by a 52-week double-blind treatment period during which participants were randomised to either continue on tirzepatide or switch to placebo