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Receptor mapping of these contact pairs revealed that transducer binding resulted in a network of contacts at the lower half of GLP-1R shared across agonist-bound structures
However, combining GLP-1 to estrogen delivers additional efficacy relative to GLP-1 alone on insulin sensitivity and glucose homeostasis in non-diabetic mice
All the three transactivation domains are able to recruit co-activators and histone acetyltransferases including CREB binding protein (CBP) and Brahma-related gene1 (BRG1) to promote gene expression [14]
These findings are supported by in vitro studies using either murine or human cells
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