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The same caution applies to combining it with any other GLP-1 or incretin agent: doing so compounds the class effects and the class risks, and there is no documented protocol for it

Moreover, HMGB1 levels rise in parallel with the severity of the disease, and thus, this protein presents a potential therapeutic target as one of the biomarkers of MASLD [228, 229]

This process is gentle and removes the water that would otherwise facilitate degradation

Indeed, the crude HR for death (with MOF as a censoring event) in the GLP-1 RA group with the DPP-4i group as reference was 0.94 [0.771.15]