Comprehensive management of tophi requires sustained, effective urate-lowering therapy, with serum urate levels maintained below 0.30 mmol/L to reduce overall crystal burden (197)
Less frequently reported adverse reactions (less than 1% or less than twice rate of placebo) included palpitations, diarrhea, nausea, decreased appetite, dizziness, agitation, depression, paranoia and restlessness
Multiple studies have posited a role for NMDA receptor activity in migraine physiology, leading some to speculate that migraine is a state of altered brain excitability
Lets talk: The full results from Lillys ATTAIN-1 trial were published in the NEJM this week, evaluating orforglipron for obesity treatment
166 In a study of 117 car battery industry workers with occupational lead poisoning, garlic (1,200 mg dried powder) daily for four weeks lowered blood lead as effectively as D-penicillamine (by approximately 18%)