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Importantly, the authors of this work similarly did not interpret their findings related to cerebrovascular resistance as negative adaptations to RT, but instead consider the increase to be a protective response to reduce the effects of increased mean arterial pressure on the cerebral circulation - where hyperperfusion can damage the microvasculature (Thomas et al., 2021)

doi: 10.1016/j.bbagen.2012.09.018

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Because of their substantial benefit on some of the most highly prevalent disorders worldwide, GLP-1RAs have been hailed as game changers 8,9 and breakthrough drugs 10 , with an estimated market value of US$22.4 billion in 2022 and a compound annual growth rate of around 9.6% between 2023 and 2032 11