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Compared with normal renal function, the estimated ratio of the mean AUC 0 was 1.23 (90% confidence interval [CI], 0.911.66) in mild impairment, 1.18 (0.871.59) in moderate impairment and 1.21 (0.871.68) in severe impairment

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The results demonstrate that both eumelanin and pheomelanin are redox-active, they can rapidly (sec-min) and repeatedly redox-cycle between oxidized and reduced states and pheomelanin possesses a more oxidative redox potential

Waddington coined the term epigenetics to describe the new branch of biology, which describes the regulation of gene transcription and genomic stability without involving alterations in the DNA sequence