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The increased oxidative stress seems to be the second hit in the progression from NAFL to NASH: the increase in ROS and consequently in lipid peroxidation has been associated to hepatocellular damage, inflammation, and eventual fibrosis due to the activation of hepatic stellate cells

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According to the model, the OCRto corresponds to the inverse of the slope and the TOCC corresponds to the inverse of the y-intercept of the above equation (See Figure 2)

These are monitored closely, and your physician will adjust your plan to minimize discomfort and ensure safety