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Description

In some embodiments, the otic formulation or composition comprises about 6% by weight of the carbomer

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Kynurenine activation of AhR leads to enhancement of oxidative stress and inflammation as a result of increased expression of the cytochrome P450 enzymes encoded by the CYP1A1 and CYP1B1 genes, the interleukin-6 (IL-6) gene, and the transforming growth factor beta 1 (TGFB1) gene