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But the really impressive numbers came from the SURPASS-5 trial, where tirzepatide reduced total cholesterol by 12.9%, LDL cholesterol by 15.5%, and triglycerides by a substantial 24.9%, while increasing HDL cholesterol by 0.9%

Its GLP-1 activity drives appetite suppression through central nervous system satiety signaling, slows gastric emptying, and enhances glucose-dependent insulin secretion

Deregulated immune cell recruitment orchestrated by FOXM1 impairs human diabetic wound healing

Participants who experienced greater weight loss during treatment were more likely to regain weight after stopping medication

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