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One candidate mechanism underlying this neuroprotective effect lies in the ability of metformin to improve insulin sensitivity, reduce chronic inflammation, and exert direct effects on brain cells [24]

GLP-1 medications are a class of treatments that help regulate appetite, blood sugar, and metabolism

Only 20% had diabetes

That observation is now opening up the drugs to clinical trials for diseases that seem less obviously related to metabolic disorders, including Alzheimers, Parkinsons, depression and even cancer

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