Mice were placed in metabolic cages for assessment of physical and metabolic parameters, including food intake, respiratory exchange ratio, energy expenditure, and locomotion activity, for 3 consecutive weeks during anti-CD38 antibody (CD38) treatment (Fig
EX long-acting preparation can reduce weight, but there are few related clinical studies, and most focus on patients with T2DM
Using VA healthcare records, we emulated a randomized trial following more than 333,000 adults with type 2 diabetes for up to three years, testing 16 different treatment scenarios continuous use, discontinuation at various time points, interruption, and restart
Inflammation Chronic inflammation is a key driver of metabolic dysfunction in obesity, with adipose tissue secreting cytokines like TNF-, IL-6 and IL-1 that disrupt insulin signaling and fuel disease progression
YA-W: Conceptualization, Funding acquisition, Investigation, Project administration, Supervision, Validation, Visualization, Writing review and editing
