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The untreated animals developed prominent edema of the face, lips, snout, paws, and scrotum, along with extreme cyanosis, poor respiration, and fatalities

5 According to 2023 CDC data, in the United States 40.1 million people have diabetes, with type 2 diabetes representing 90% to 95%, or an estimated 36 38 million people living with type 2 diabetes, making it the most common form of the disease

Nevertheless, ClinicalTrials.gov

Dosing Range (Systemic ): Research protocols typically use very low doses, often in the microgram (mcg) range, or low single-digit milligrams (mg) per day, reflecting its high biological potency as a signaling molecule

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