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The suggested frequency of coffee enemas varies

Qi H, Li Y, Liu X, Jiang Y, Li Z, Xu X, et al

Another study showed that elevated insulin levels promote the proliferation of thecal cells and increase the secretion of androgens, including luteinizing hormone (LH), while also upregulating the expression of cytochrome P450 and insulin growth factor-1 (IGF-1) receptors (107)

We weave together studies of normal aging, mid-life depression, LLD and neurodegenerative disease (AD and PD) to consider how age-related vulnerabilities increase the risk of LLD and how these mechanisms may, in turn, heighten vulnerability to neurodegeneration

This protective "shell" allows the glutathione to travel through the digestive system intact