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Although melanomas are melanocytic tumors, they differ in cell type, age of onset, clinical and histologic manifestations, metastatic pattern, ethnic distribution, role of ultraviolet radiation in disease onset, predisposing changes in the germline, mutational processes, and pattern of somatic mutations [1]

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Very few have been explored for direct interactions with the BBB thus many opportunities still exist to explore the physiological effects of these metabolites [145, 146]