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A genome-wide association study identifies CDHR3 as a susceptibility locus for early childhood asthma with severe exacerbations

TNF- modulation of intestinal epithelial tight junction barrier is regulated by ERK1/2 activation of Elk-1

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One illustrative example of the role of free radicals in autoimmune disease is rheumatoid arthritis (RA)

Endogenous IL-1 has been reported to be insufficient for activating and recruiting neutrophils, and even high pharmacological doses of IL-1 fail to exacerbate APAP-induced liver injury, indicating that IL-1 signaling is not a critical contributor to APAP-induced hepatotoxicity