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For approved clinical care in Canada: Tirzepatide is the only option

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Human embryonic stem cell-derived MSCs can also treat CTX-induced POF mice, potentially through paracrine mechanisms that involve the secretion of VEGF, IGF-2, and hepatocyte growth factor which help improve ovarian function, reduce granulosa cell apoptosis, and restore fertility [129]

Semaglutide for weight loss received FDA approval in June 2021 and Health Canada approval in November 2021, representing a relatively quick turnaround