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Whats more, a recent retrospective, multicenter cohort study denied higher occurrence of nonarteritic anterior ischemic optic neuropathy (NAION) in GLP-1RAs users and suggested that its potential benefits for blood glucose control and cardiovascular health likely outweigh its risks (Table 1

We start with a low dose and gradually increase to minimize side effects

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The occluded positioning of the RGKT motif in the ASK1MAX2HTL7SMAX1 complex makes it an unlikely ubiquitination site, suggesting that its loss impairs D53 ubiquitination by destabilising the complex