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This partially reflects the same phenomenon we see for medicines: given the complexity of PCOS and the diversity of its clinical manifestations, biomarker research aims to explore a larger number of pathways including metabolic biomarkers than for the fewer symptomatic manifestations of endometriosis

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While at higher concentrations nitric oxide (NO) is detrimental and contributes to neuroinflammation and neurodegeneration, at normal physiological levels, the role of NO is integral within the brain for neurotransmission (modulates serotonin, dopamine, and norepinephrine), neuromodulation, and synaptic plasticity (Dvokov et al., 2006)