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This complementary action enables greater HbA1c reductions than either agent alone, with clinical trials demonstrating additive effects on glycemic control

- This study investigated the association of semaglutide 2.4 mg with major adverse cardiovascular events among individuals with overweight/obesity without diabetes who had risk factors for atherosclerotic cardiovascular disease.- This study investigated the association of semaglutide 2.4 mg with major adverse cardiovascular events among individuals with overweight/obesity without diabetes who had risk factors for atherosclerotic cardiovascular disease.- 48,184 patients initiating semaglutide 2.4 mg were propensity-score matched 1:2 to those not on semaglutide 2.4 mg (96,368 individuals).- In this study, semaglutide 2.4 mg was associated with a lower risk of incident major adverse cardiovascular events and heart failure composite outcomes.- Exploratory analyses further demonstrated consistent lower risks of obesity-related outcomes, including incident type 2 diabates, major adverse kidney events, acute kidney injury, major obesity-related adverse events, and all-cause hospitalization.Association between semaglutide 2.4 mg and risk of cardiovascular events in people with overweight or obesity without atherosclerotic cardiovascular disease in the real-world: The SCORE primary prevention study (open access) doi.org/10.1016/j.ajpc

injection sites and medication-level context are not its core design

An aminoisobutyric acid (Aib) substitution at position 8 resists degradation by the DPP-4 enzyme

This can lead to build-up of toxins in the liver and other organs, damage to cells requiring more cellular repair, and the inability of energy production