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It should not be used by pregnant or breastfeeding women or young children, as it may elevate bilirubin, causing jaundice or yellowing of the skin and eyes

Moreover, besides binding of minor fraction of Cu(II) ions, His can also act as a catalyst enhancing the rate of the copper transfer between CuHSA and other proteins and cellular destinations, which might be the most important physiological role of His in copper metabolism

For beauty industry customers, this pathway is generally not relevant because Pure GHK-Cu is mainly used as a topical cosmetic ingredient

This is particularly relevant during the initial weeks of treatment when gastrointestinal side effects are most pronounced

When I first started taking it, I was very tired, had no appetite, and felt quite nauseous