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The GLP-1 receptor is expressed in all these subcortical target regions and also in cortical and hippocampal regions that do not get axonal input from the GLP-1 neurons in the hindbrain (Randolph et al., 2024)

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Prioritising adequate protein intake (approximately 11.2 g/kg/day) often helps sustain progress without unnecessary dose escalation

doi: 10.1586/era.10.43 32 MaliBJarmTSnojMSersaGMiklavcicD

This stimulates insulin release when glucose is high, reduces liver glucagon production, slows stomach emptying to control post-meal sugar spikes, and increases fullness to reduce appetite and food intake