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The Hypothalamic-Pituitary-Adrenal (HPA) axis is the bodys central stress response system

KPV for airway inflammation Research published in the journal Biological Chemistry demonstrated that KPV and its related melanocortin peptide gamma-MSH suppress NF-kB signaling in airway epithelium through two distinct mechanisms: inhibition of p65 nuclear import (KPV) and epithelial MC3R activation (gamma-MSH)