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Discrepancies between prevalence and incidence data leads to variability in epidemiological data which is attributable to the diverse populations and its genetics, differences in disease classification, cultural and social differences, lack of screening or diagnostic tests, social and cultural stigma attached to the disease, and inconsistent reporting by patients

While Wu et al (202) recently addressed lactate-regulated ferroptosis in cancer contexts and acknowledged the context-dependent nature of this phenomenon, their analysis did not elucidate the mechanistic determinants underlying this differential regulation