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However, this technique is impractical in the clinical setting and it is mostly used for research purposes
This was despite some concerns outlined in briefing documents regarding Lillys trial methodology, including its use of the integrated Alzheimers Disease Rating Scale (iADRS) as the primary endpoint, the use of tau protein levels to decide study inclusion and the cessation of donanemab treatment in patients whose brain amyloid levels dropped past a certain, pre-specified threshold
Furthermore, sustainable GLP-1 coverage requires a framework that supports both medication users and non-users while aligning clinical outcomes with financial predictability
Serious but rare complications include primary pulmonary hypertension and valvular heart disease, though those associations come primarily from older studies involving fenfluramine combinations rather than phentermine alone
However, current research does not fully support this concern
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