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I've got to do that because otherwise I somehow cheated myself," Winfrey said in September 2023 during a panel on Oprah Daily, called "The State of Weight." It was after that discussion that she changed her mind about using a weight-loss drug, Winfrey told People, calling it her "biggest aha" moment: "I realized I'd been blaming myself all these years for being overweight, and I have a predisposition that no amount of willpower is going to control." Frustration with her weight has "occupied five decades of space" in her brain, she noted