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Have Digestive Disorders: Conditions such as Crohns disease or coeliac disease can impair the absorption of B12 from food

Of the adverse experiences judged to be of possible relationship to the study drug, anxiety, incoordination, and nervousness were reported following intramuscular vitamin B 12 and headache, nausea, and rhinitis were reported following dosing with Nascobal (Cyanocobalamin, USP) Gel for Intranasal Administration

CYP2D6 exhibits a marked genetic polymorphismover 70 alleles (www.cypalleles.ki.se/cyp2d6.htm) have been described whose combination leads to four phenotypes: poor, intermediate, extensive, and ultrarapid metabolizers (PM, IM, EM, and UM, respectively)

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adults (margin of error +/- 3 percentage points)