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In Phase 3 TRIUMPH-4, retatrutide at 12 mg produced 28.7% body weight loss at 68 weeks vs 2.1% for placebo

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Study inclusion criteria limited research subjects to males between the ages of 18 and 35 years, who reported participation in at least two weekly resistance training sessions over the six-month period immediately prior to the start of the study

However, these findings are notably inconsistent across studies

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