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Cold medication might contribute to injection discomfort for some patients

A plausible explanation could be a reorientation of Lys105 towards GS resulting in a decreased stabilization of the active site thiolate as a leaving group

doi: 10.1210/clinem/dgaa374 59 PetrelliAGiovenzanaAInsalacoVPhillipsBEPietropaoloMGiannoukakisN

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Additionally, SASP includes proteases like MMPs, which, while degrading some ECM components, also remodel the matrix in ways that can facilitate fibrosis progression and release matrix-bound growth factors (like TGF-) [28]