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Another study found that LCACs modulate genes encoding the alpha subunit of the potassium channel and promote the development of arrhythmias (Spiekerkoetter et al., 2009)

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Propionyl-L-carnitine shows particular promise for peripheral vascular disease and heart failure, with some trials demonstrating improved exercise tolerance.[8][9] LCAR supplementation improves glucolipid metabolism, reducing fasting glucose, insulin resistance, triglycerides, and liver enzymes.[10] Both compounds exhibit excellent safety profiles with minimal side-effects, though recent data raises concerns about substantial TMAO production (reaching 50 M plasma levels) from both supplements, which may have adverse cardiovascular implications.[1][8][3] References Potential Therapeutic Role of Carnitine and Acetylcarnitine in Neurological Disorders

McCartney CR, Campbell RE, Marshall JC, et al

Molecular Biology of the Cell (4th ed.)