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4 Discussion Compared with RG group, more reductions of Scr, BUN, UA, and better improvement of eGFR were observed in RG + CHF group

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Several decisions were close, and the committee heard substantial disagreement about chemical characterization, peptide-related impurities, immunogenicity, carcinogenicity signals or uncertainty, the limited quantity and quality of human evidence, and whether existing FDA-approved therapies already address the proposed uses

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