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Finally, both hydrophilic and lipophilic statins, which inhibit hepatic HMG-CoA reductase, appear to exert similar cholesterol-independent effects, despite the relative impermeability of hydrophilic statins in vascular tissues

57 On the other hand, the reduction in energy intake during an ad libitum lunch (buffet style) with tirzepatide 15 mg (348.4 kcal) was not significantly different compared to semaglutide 1 mg (284.1 kcal, P =0.19) which may suggest that mechanisms other than reduced food intake and appetite are contributed to the more WL observed with tirzepatide 15 mg versus semaglutide 1 mg

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J Struct Chem