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Additionally, glutamate receptors become more sensitive to excitatory stimuli in the presence of neuroinflammation, leading to enhanced excitotoxicity, which damages neurons and accelerates neurodegeneration

139 This is consistent with the hypothesis that elevated canonical Wnt signalling contributes to the hyperproliferation of embryonic neural progenitor cells (NPCs) in the brain, which may partially explain the macrocephaly observed in individuals with autism

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