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Insulin resistance in obesity can be reliably identified from fasting plasma insulin

This is in line with the reported specificity of CPA, which is C-terminal amino acid residues with branched aliphatic or aromatic side chains 64

Some studies have shown greater average weight loss with tirzepatide compared with semaglutide, but the best choice depends on the patients medical history, treatment goals, side-effect tolerance, metabolic risk, and physician evaluation

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More recently, the European Medicines Agency Pharmacovigilance Risk Assessment Committee concluded that the available evidence does not at present support a causal association between GLP-1RAs and suicidality 237