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Intrinsic factor is essential for B12 absorption in the terminal ileum

The Aib 13 of tirzepatide seems to lower its GLP-1 activity without affecting its GIP activity, and to destroy its GCG activity

This is why dosing typically occurs weekly rather than daily, a significant advantage for research protocols and compliance

More research efforts are needed to develop guidelines regarding GLP-1 RA dose adjustments or discontinuations before such procedures and to improve both, procedural and patient-related, outcomes

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