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Estradiol promotes anti-apoptotic pathways by enhancing the transcription of anti-apoptotic genes such as B-cell lymphoma 2 (BCL2) (202) and inactivating pro-apoptotic proteins such as BAD (BCL2 associated agonist of cell death) (203, 204)

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The proposed mechanism described in papers that were later retracted is that it potentiates hepatocyte growth factor (HGF) signaling at the c-Met receptor, driving dendritic spine formation and synaptogenesis

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The some by mi galactomyces glutathione glow serum mask review shows that this combination is generally well-tolerated