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Excited to share that the final chapter of my PhD thesis is now published in the Journal of Medicinal Chemistry ( Although reactivity with glutathione is commonly used as a proxy for metabolic liability of covalent drugs, in this work we show that the intrinsic reactivity (electrophilicity) of covalent warheads is not a reliable predictor of their in vivo metabolic susceptibility
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L-Glutathione cannot be properly synthesized in people with liver disorders such as liver cancer, hepatitis, etc
Gradual escalation allows physiological adaptation to each dose level before increasing
I bought saltines and white rice in case I was nauseous
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