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This D-retro-inverso configuration preserves the three-dimensional side-chain topology of the original FOXO4 sequence maintaining functional mimicry of the FOXO4 forkhead domains interaction surface with p53 while conferring exceptional proteolytic stability compared to the native L-amino acid sequence

J Chem Soc Trans

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FIGURE 4 Given the marked effects of HC on cell proliferation and migration, we next assessed whether HC treatment triggered apoptotic cell death