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A population PK analysis in patients with major depressive disorder showed no substantial change in plasma concentrations of fluoxetine (20 mg/day or 40 mg/day), paroxetine CR (37.5 mg/day or 50 mg/day), or sertraline (100 mg/day or 150 mg/day) dosed to steady-state

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As regards the fibrinolytic process, an impairment of the binding and action of tissue-type plasminogen activator (t-PA) at the endothelial cell surface has been reported in the presence of homocysteine, which would thus inhibit endothelial-dependent fibrinolysis (Hajjar, 1993)

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