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Glutathione Supplementation Improves Macrophage Functions in HIV Devin Morris, Carlos Guerra, Melissa Khurasany, Frederick Guilford, Beatrice Saviola, Ying Huang, Vishwanath Venketaraman Published May, 2013 in the Journal Interferon and Cytokine Research The results indicate that HIV infection leads to increased production of free radicals and decreased production of GCLC resulting in depletion of rGSH and this may lead, in part, to the loss of innate immune function observed in HIV patients